Assessment of the impact of rivaroxaban on coagulation assays: Grupo Latinoamericano de Estudio de Lupus: Thrombophilia, Protein C, Resistance. Thrombophilia testing in patients taking direct oral anticoagulants. This article has been cited by other articles in PMC. Molecular genetic analysis in mild hyperhomocysteinemia: Compliance with Ethical Standards Conflict of interest The authors declare no conflict of interest.
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Sticky platelet syndrome: history and future perspectives.
The method hematologiaa by Mammen [ 6 ] was used: For the detection of the p. As a result of studying these conditions in more than Mexican mestizos, we have been fhndamentos to define the thrombophilic conditions prevailing in the Mexican population, which express differences to those identified in other populations of the world [ 4 ].
Thrombophilia, Protein C, Resistance. These data are consistent with those observed in other populations and identify that consideration be given as to whether individuals are being treated with the novel DOACs when conducting laboratory studies oriented to identify the etiology of thrombosis [ 24 ].
Fundamentos de Hematología – Google Books
The detection of the transition c. Salient findings in thrombophilic patients with abnormal or normal activated protein C resistance phenotype aPCR. We further identified additional causes of abnormal aPCR phenotype: Indian J Hematol Blood Transfus.
Briefly, a fragment of the prothrombin gene comprising nucleotides 19,—20, was amplified by PCR. Grupo Latinoamericano de Estudio de Lupus: Although FV Leiden is the major cause of hereditary aPCR, it is becoming increasingly clear that several other genetic and acquired conditions contribute to aPCR and thereby increase the risk of venous thrombosis [ 18 — 21 ].
Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly hmeatologia coagulation assays.
Furthermore, autoimmune diseases predicted each other, i. Compliance with Ethical Standards Conflict of interest The authors declare no conflict of interest. Abnormal results for platelet aggregation with three concentrations of ADP 2. Materials and Methods Patients During a month period, all consecutive Mexican mestizo patients referred to our clinic by physicians from different parts of the country were prospectively accrued in the study, if they had one of the following clinical markers associated with a primary hypercoagulable state [ 1 — 4 ]: Assessment of the impact of rivaroxaban on coagulation assays: In this study we have analyzed some of the causes, both inherited and acquired, of the aPCR phenotype in a group of Mexican mestizos with a history of a thrombotic episode in the presence of a clinical marker of thrombophilia.
Normal controls were studied for each case. The highly efficient algorithm C4. Morgan Kaufmann Publishers; In a single institution for a month period, 96 Mexican mestizos with a history of thrombosis and clinical markers of a primary thrombophilic state were prospectively studied to identify henatologia thrombophilic condition.
During a month period, all consecutive Mexican mestizo patients referred to our clinic by physicians from different parts of the country were prospectively accrued in the study, if they had one of the following clinical markers associated with a primary hypercoagulable state [ 1 — 4 ]: The mutation was identified by restriction analysis with BstNI. Published online Dec Interestingly, when looking at the rule sets for aPCR phenotype, in all cases only the status of FV Leiden mutation had been considered relevant for the classification.
Molecular genetic analysis in mild hyperhomocysteinemia: Received Jun 15; Accepted Dec Castoldi E, Rosing J.
This process was repeated permutating the attributes until each attribute had been selected once as target attribute. As the number of cases in our study was small, the complete data set was randomly split into 10 subsets with approximately equal distribution of classes and number of cases. Each case is defined by the values of the attributes sticky platelet syndrome, FV Leiden, Cambridge, Hong Kong and Liverpool mutations, c. Acquired activated protein C resistance cause by lupus anticoagulants.
How we study and treat patients with suspected thrombophilia.